Application of air compressor in the production of pharmaceutical intermediates

Application of air compressor in the production of pharmaceutical intermediates

1. Core demand for compressed air in pharmaceutical intermediate production

Pharmaceutical intermediates production needs to meetGMP (Good Manufacturing Practice)Standards for compressed airCleanliness, stability, safetyThe requirements are extremely high. As a core power equipment, air compressors need to provide compressed air that meets the following characteristics:

1. No oil and no pollution: Avoid contaminating products with lubricants, particulate matter, and microorganisms.
2. constant voltage stability: Ensure accurate operation of reaction tanks, pneumatic valves and other equipment.
3. high-efficiency energy-saving: Reduce production costs and meet environmental protection requirements.

2. Specific applications of air compressors in the production of pharmaceutical intermediates

3. Key technologies of air compressors in the production of pharmaceutical intermediates

1. Oil-free technology
   • Dry oil-free screw air compressor: Ensure no oil contact during compression through special coating or sealing technology.
   • Water-lubricated oilless screw air compressor: Use water as the lubricating medium to avoid oil pollution, but the water quality needs to be changed regularly.
2. clean technology
   • multistage filtration system: Configure pre-filter, activated carbon filter, and ultra-high efficiency filter (HEPA) to remove particulate matter, oil mist, and microorganisms.
   • Cold dryer + dry dryer combination: Reduce the dew point of compressed air to below-40℃ to prevent moisture from affecting product quality.
3. energy-saving technology
   • Permanent magnet frequency conversion technology: Automatically adjust the speed according to the actual air consumption, and the energy saving rate can reach 30%-50%.
   • waste heat recovery system: Recover heat generated by air compressor operation and use it for process heating or domestic hot water.

4. Key points of selection of air compressors in the production of pharmaceutical intermediates

1. cleanliness level
   • The pharmaceutical industry usually requires compressed air to achieveISO 8573-1:2010 Class 0(No oil, no water, no particles).
2. stability requirements
   • Choose to haveredundancy designThe air compressor system (such as double machines in parallel) ensures production continuity.
3. Maintenance convenience
   • Give priority to models with modular design and easy maintenance to reduce downtime.
4. compliance certification
   • Air compressor needs to passCE、UL、ASMEOther international certifications are in line with the regulatory requirements of the pharmaceutical industry.

5. Typical case: Air compressor application in a pharmaceutical intermediate manufacturing enterprise

• corporate background: An annual output of 500 tons of an anti-cancer drug intermediate must meet FDA certification.
• Air compressor configuration：
  • Main air supply system: 2 oil-free dry screw air compressors (one for use and one for standby), equipped with cold drying machines and three-level filters.
  • Laboratory system: 1 oil-free centrifugal air compressor providing high-purity carrier gas.
• energy saving effect: Through permanent magnet frequency conversion technology, it saves electricity by about 500,000 kilowatt-hours per year and reduces carbon emissions by 300 tons.

6. Future trend: The technical development direction of air compressors in the production of pharmaceutical intermediates

1. digital and intelligent
   • Integrate Internet of Things (IoT) technology to achieve remote monitoring, fault warning, and energy consumption analysis.
2. Green energy integration
   • Combine photovoltaic and energy storage systems to create a zero-carbon air compressor station.
3. Miniaturization and integration
   • Develop compact air compressors to adapt to scenarios where space is limited in pharmaceutical workshops.

VII. Conclusion

Air compressors play the role of “invisible arteries” in the production of pharmaceutical intermediates, and their performance directly affects product quality and production efficiency. Enterprises need to choose based on factors such as production process, cleanliness requirements, and cost budget.Oil-free, clean, stable and energy-savingWe have established a sound maintenance and management system to ensure compliance with GMP standards and ensure the safe and efficient production of pharmaceutical intermediates.