What are the requirements of the bio-industry for air quality?

In the bio-industry, air quality is crucial to the stability of the production process and product quality. Its requirements mainly include the following aspects:

1. Core requirements

1. sterile: Sterility is the primary requirement for air quality in the bio-industry. The normal growth and reproduction of microorganisms requires a clean air environment, and sterility can prevent fermentation failure caused by miscellaneous bacterial pollution. It is generally required that only one contamination is allowed in 1000 fermentation cycles, that is, the sterility of the filtered air is N=10 ³.
2. No dust, no impurities, no water, no oil: These substances may have adverse effects on microorganisms or fermentation products and therefore require strict control.
3. proper temperature and humidity: It can ensure microbial activity and promote the smooth progress of the fermentation process.
4. maintain a positive pressure: It can prevent untreated external air from entering the fermentation system and avoid contamination by miscellaneous bacteria.

2. Specific parameters

1. Pressure of compressed air: The air pressure at the outlet of the air compressor is usually between 0.2 and 0.35MPa to meet the needs of different process links.
2. air flow: Determine according to production scale and process requirements to ensure sufficient air in fermentation tanks and other equipment.
3. the temperature of the air: The temperature of the compressed air entering the fermentation tank is generally 10 ° C higher than the fermentation temperature to maintain a suitable temperature in the fermentation tank.
4. relative humidity: The relative humidity of the compressed air entering the main filter is controlled at 60%~70% to prevent moisture from having adverse effects on microorganisms or fermentation products.

3. Air purification and sterilization methods

In order to meet the above requirements, the following air purification and sterilization methods are often used in the bio-industry:

1. media filtration: Use regularly sterilized drying media (such as cotton, glass fiber, activated carbon, etc.) to intercept microorganisms contained in the air flowing through to obtain sterile air.
2. radiation sterilization: Use X-rays, beta rays, ultraviolet rays, etc. to destroy the activity of microbial proteins to play a bactericidal role. However, the sterilization efficiency is low and generally needs to be combined with other methods.
3. Chemical sterilization: Use chemicals (such as formaldehyde, phenol, etc.) to kill microorganisms in the air. However, attention should be paid to the residue of chemicals to ensure that they do not have adverse effects on the fermentation process.
4. heat sterilization: Use high temperatures to kill microorganisms in the air. However, it requires consuming a large amount of energy and adding heat exchange equipment, which is not economical in industrial production.
5. electrostatic adsorption: Use electrostatic attraction to adsorb charged particles to achieve the purpose of sterilization and dust removal. It is often used for pretreatment of sterile air required for clean benches and clean studios.